CAMP Responsive Element Modulator (CREM) (C-Term) Peptide
CREM
Reactivity: Human, Rat
Host: Synthetic
BP, WB
Catalog No. ABIN1540899
Quick Overview for CAMP Responsive Element Modulator (CREM) (C-Term) Peptide (ABIN1540899)
Target
CREM
(CAMP Responsive Element Modulator (CREM))
Origin
Human, Rat
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- KNREAARECR RKKKEYVKCL ENRVAVLENQ NKTLIEELKA LKDLYCHKAE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Crem Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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CAMP Responsive Element Modulator (CREM) peptide
CREM Reactivity: Human, Rat, Cow, Mouse Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CREM (CAMP Responsive Element Modulator (CREM))
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Background
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Crem is a transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Delta is an activator. Crem plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform Tau (activator) to CRE is increased by CREB3L4. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange.
Alias Symbols: Icer
Protein Size: 357 -
Molecular Weight
- 39 kDa
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Gene ID
- 25620
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NCBI Accession
- NM_001110860, NP_001104330
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UniProt
- Q03061
Target
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